Dear Colleagues,

Cancer is a leading cause of death worldwide, but new developments in nanotechnology are expected to improve the therapeutic efficacy while decreasing the side effects of anticancer drugs on healthy organs by taking advantage of the tumor microenvironment. The tumor microenvironment possesses an intricate structure and constituents that are distinct from those of normal tissues, for example, dysfunctional blood vessels, acidic pH values, excess levels of GSH, and over-expressed enzymes, which not only promote tumor angiogenesis and metastasis but are also responsible for therapeutic resistance and treatment failure. Nanomedicines, based on organic, inorganic, lipid, protein, or glycan compounds as well as on synthetic polymers, have been designed to change their physicochemical property once they arrive at the tumor site and are triggered by the tumor microenvironment to increase cancer therapeutic outcome, reverse the multidrug resistance of cancer, inhibit tumor angiogenesis, etc.

Nanoparticles also hold considerable promise in biomedical imaging, which is indispensable for assessing therapeutic intervention and reflecting the dynamic changes of cancer. For example, macroscopic imaging can measure lesion size, lesion metabolism, metastasis, etc.

This Special Issue is designed to gather scientific papers on nanomedicines for cancer treatment. Potential topics may include (but are not limited to): i) nanomedicine in cancer therapy; ii) nanomedicine in cancer imaging; iii) nanomedicine-based cancer immunotherapy.

Dr. Yapei Zhang
Prof. Dr. Zhi Yuan
Guest Editors

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• nanoparticle
• cancer therapy
• cancer imaging
• immunotherapy
• tumor microenvironment